Abnormal Toxicity & Pyrogen Testing
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Abnormal Toxicity & Pyrogen Testing
The absence of pyrogens in injectable drugs is an indispensable safety control because contaminants causing fever to pose a life-threatening risk to the patient resulting in the worst case in death by shock. When fever-inducing agents, i.e. pyrogens, come into contact with the immunocompetent cells in the blood, these cells release mediators, which transmit the fever signal to the thermoregulatory centers of the brain.
The in vivo rabbit pyrogen test, which measures the fever reaction following the injection of the sample into the animals.
Comprehensive Pyrogen Testing at Apollo Bioscienc
At Apollo Bioscience, we leverage both traditional and advanced pyrogen testing methodologies to ensure the highest safety standards for injectable drugs and medical devices. Our comprehensive testing services include:
- Rabbit Pyrogen Test: This in vivo test remains a cornerstone for detecting pyrogens, particularly in regulatory environments that require it.
- Monocyte Activation Test (MAT): An in vitro alternative that offers a humane and precise method for pyrogen detection.
- Limulus Amebocyte Lysate (LAL) Test: This test detects endotoxins, a specific type of pyrogen, using an enzyme found in horseshoe crab blood.
Partnering with Apollo Bioscience
By choosing Apollo Bioscience for your pyrogen and abnormal toxicity testing needs, you are partnering with a leader in bioscience research committed to advancing the safety and efficacy of pharmaceutical products. Our comprehensive testing services are designed to support your product development process from early-stage research through to regulatory submission and beyond.
Contact Us For Excellent Service
For more information about our pyrogen and abnormal toxicity testing services, or to discuss your specific testing requirements, please contact us at: