Product Development for NCE and Biopharmaceuticals
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Product Development for NCE and Biopharmaceuticals
Pre-clinical lead optimization is the early assessment of a compound’s development potential. Lead optimization reduces the risks associated with selecting the wrong candidate and progressing it through pre-clinical and clinical development. It is a way of reducing both the cost and time associated with drug development, while also producing a stronger patent position and improving possibilities for global partnerships.
It is important to consider early the required product characteristics in terms of efficacy and side effects, the anticipated patient groups, how the product will be used and the cost of goods. The motto ‘fail fast, fail cheap’ is vital in the industry. The typical progression pathway for a small /large molecular entity begins in the discovery phase. Once a ‘Hit’ is detected against a target (through screening, computation or identification of a pharmacophore), and then the ‘Hit-to-lead’ transition occurs through lead optimization studies. It is this leadership transition that is the first important part of the pre-clinical development process. Lead optimization studies identify which compounds have the necessary pharmaceutical properties for rapid and uncomplicated development.
Fast and cost-effective method to decide the fate of the molecule.
- Fast and only the critical-parameter assessment in vivo screening with the minimum number of animals.
- PK screen.
- Metabolic stability and ADME screen.
- Ames, Micronucleus, mouse lymphoma test.
- Acute toxicity
Why Choose Apollo Bioscience for Lead Optimization?
At Apollo Bioscience, we are committed to excellence in bioscience research and development. Our state-of-the-art facilities, coupled with our team of experienced scientists, ensure that we provide top-tier lead optimization services. By partnering with us, you can expect:
- Customized Solutions: Tailored lead optimization strategies to meet your specific project needs.
- Cutting-Edge Technology: Utilization of the latest technologies and methodologies in bioscience research.
- Expertise and Experience: Decades of combined experience in drug discovery and development.
- Collaborative Approach: Close collaboration with your team to ensure alignment with your goals and objectives.
Apollo Bioscience is your trusted partner in navigating the complexities of lead optimization, ensuring that you advance only the most promising candidates through the drug development pipeline.
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